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Lactate Clearance vs Central Venous Oxygen Saturation as Goals of Early Sepsis Therapy: A Randomized Clinical Trial
sepsis septic shock emergency medicine mortality
2014/11/28
Context Goal-directed resuscitation for severe sepsis and septic shock has been reported to reduce mortality when applied in the emergency department. Objective To test the hypothesis of noninferiorit...
The Chest Pain Choice trial: a pilot randomized trial of a decision aid for patients with chest pain in the emergency department
emergency medicine chest pain acute coronary syndrome
2014/11/28
Background: Chest pain is a common presenting complaint in the emergency department (ED). Despite the frequency with which clinicians evaluate patients with chest pain, accurately determining the risk...
Effectiveness of the Chest Pain Choice decision aid in emergency department patients with low-risk chest pain: study protocol for a multicenter randomized trial
D-dimer pulmonary embolism venous thromboembolism testing
2014/11/28
Background: Chest pain is the second most common reason patients visit emergency departments (EDs) and often results in very low-risk patients being admitted for prolonged observation and advanced car...
Randomized Trial of Tenecteplase or Placebo with Low Molecular Weight Heparin for Acute Submassive Pulmonary Embolism: Assessment of Patient-Oriented Cardiopulmonary Outcomes at Three Months
tenecteplase pulmonary embolism
2014/11/28
Background: Acute submassive pulmonary embolism (PE) with right ventricular (RV) injury and/or concomitant deep venous thrombosis can cause persistent symptoms that degrade quality of life. We tested ...
Prospective, randomized evaluation of a personal digital assistant-based research tool in the emergency department
personal digital assistants data collection emergency department
2014/11/28
Background Personal digital assistants (PDA) offer putative advantages over paper for collecting research data. However, there are no data prospectively comparing PDA and paper in the emergency depart...